I liked what they had to say about comments and reader feedback:

[Interviewer]: You don’t (appear to) allow comments on your comics or your blog. How do you engage with your audience? How do you know you’re on the right track, or do you not care?

DREW: I totally appreciate feedback. We publish our email addresses, and people can Twitter at us or post on our Facebook fan pages. Having people leave comments directly on the sites just seems counterproductive. Anyone who wants to write about our work is welcome to embed our comics into their blog and talk about them, or link to them from Twitter/Facebook and post their opinion, etc. But nobody’s going to put one of my comics on their own blog and write “First” underneath it.

The idea behind comments is that you learn what your readers think of your work. A more effective way for us to measure this is to see what people are linking to on Twitter, which images get passed around blogs, what shows up on Digg/Reddit, and so on. I have no doubt that a lot of our readers are funny and write well, but like you mentioned, these people get chased out when the signal-to-noise ratio drops.

NATALIE: There’s never a space under paintings in a gallery where someone writes their opinion. When you get to the end of a book, you don’t have to see what everyone else thought of it.